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10/19/2003 Archived Entry: "Hot Paper in Medicine - Risks and benefits of estrogen plus progestin in healthy postmenopausal women"

Hot Paper in Medicine - Risks and benefits of estrogen plus progestin in healthy postmenopausal women and the answer is ... Overall health risks exceeded benefits from use of combined estrogen plus progestin for an average 5.2-year follow-up among healthy postmenopausal US women. All-cause mortality was not affected during the trial. The risk-benefit profile found in this trial is not consistent with the requirements for a viable intervention for primary prevention of chronic diseases, and the results indicate that this regimen should not be initiated or continued for primary prevention of CHD [from the Women's Health Initiative Randomized Controlled Trial," by the Writing Group for the Women's Health Initiative Investigators (J.E. Rossouw, et al.), JAMA-Journal of the American Medical Association, 288(3): 321-33, 17 July 2002.]