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03/11/2003 Archived Entry: "Rhabdomyolysis, statins, cholesterol ... have we overdone it."
Rhabdomyolysis is making the news. CNN reports; "Germany's Bayer said on Monday 52 people are thought to have died after taking the anti-cholesterol product Baycol, its fastest-growing drug." According to the FDA, "FDA announced on August 8, 2001 that Bayer Pharmaceutical Division is voluntarily withdrawing Baycol (cerivastatin) from the U.S. market because of reports of sometimes fatal rhabdomyolysis, a severe muscle adverse reaction from this cholesterol-lowering (lipid-lowering) product. The FDA agrees with and supports this decision." Further details from the FDA state "Rhabdomyolysis is a condition that results in muscle cell breakdown and release of the contents of muscle cells into the bloodstream. Symptoms of rhabdomyolysis include muscle pain, weakness, tenderness, malaise, fever, dark urine, nausea, and vomiting. The pain may involve specific groups of muscles or may be generalized throughout the body." This is bad news! further ... "In rare cases the muscle injury is so severe that patients develop renal failure and other organ failure, which can be fatal." --- Kritzer/Zonies LLC state "Rhabdomyolysis is a muscle breakdown disorder. The muscle components are released into the blood circulation and detectable as an elevated CK level, usually five times higher than normal." Merriam Webster's Medical Dictionary describe the effects as "the destruction or degeneration of skeletal muscle tissue (as from traumatic injury, excessive exertion, or stroke) that is accompanied by the release of muscle cell contents (as myoglobin andpotassium) into the bloodstream resulting in hypovolemia, hyperkalemia, and sometimes acute renal failure". emedicine states: "Pathophysiology: Rhabdomyolysis is the breakdown of muscle fibers with leakage of potentially toxic cellular contents into the systemic circulation. The final common pathway of rhabdomyolysis may be a disturbance in myocyte calcium homeostasis. Clinical sequelae of rhabdomyolysis include the following:
* Hypovolemia (sequestration of plasma water within injured myocytes)
* Hyperkalemia (release of cellular potassium into the systemic circulation)
* Metabolic acidosis (release of cellular phosphate and sulfate)
* Acute renal failure (nephrotoxic effects of liberated myocyte components)
* Disseminated intravascular coagulation (DIC)"
I did not take any Baycol®, but did use Lipitor® last year ... I didn't feel well in a BIG way. I don't know yet if I suffered irreperable damage; the Baycol information makes me wonder!
on the bookshelf:
Statins and Coronary Artery Disease by D. J. Betteridge
Statins: The Hmg Coa Reductase Inhibitors in Perspective by Allan Gaw
Hmg-Coa Reductase Inhibitors (Milestones in Drug Therapy) by G. Schmitz
US CHOLESTEROL-REDUCING STATIN REPORT 2002 by MarketResearch.com
Drugs of Tomorrow 2001: Dyslipidemia - The Advent of Third Generation and Combination Statins by MarketResearch.com
Statins: The HMG CoA Reductase Inhibitors in Perspective by Allan Gaw
Metabolic Complications of Acute Arterial Occlusions and Related Conditions/Myonephropathic-Metabolic Syndrome by Henry Haimovici
Replies: 1 Comment
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Posted by EM @ 03/11/2003 08:39 PM CST